Comparison of ^99mTc-CTMP and ^99mTc-MDP in animal model as bone imaging radiopharmaceutical

1,4,8,11-tetraaza cyclotetradecyl-1,4,8,11-tetramethylene phosphonic acid (CTMP) as new agent for bone imaging have been synthesized and complexed with ^99mTc. Biodistribution of this complex in mice were carried out and the uptake in bone and other soft tissue were detailed. A comparison of the biodistribution studies of the ^99mTc-CTMP with the well-established radiopharmaceutical ^99mTc-MDP was carried out for the purpose of evaluating the efficacy of the radiopharmaceutical preparation. The bone up take of ^99mTc-CTMP complexes is 3.57, 2.90, 4.14 and 4.39 (%ID/g) at 1, 3, 5 and 24 hours respectively was lesser than those of ^99mTc-MDP which was 10.73, 10.12, 10.48, and 5.95 (%ID/g) at 1, 3, 5 and 24 hours respectively. However, due to in vivo stability ^99mTc-CTMP was better than ^99mTc-MDP. Then ^99mTc-CTMP imaging with gamma camera gave clearer image of bone. (author)