Published September 2015 | Version v1
Journal article Metadata-only

Radioprotective effects of nuclear targeting nanomaterial C60(OH)24-SLN-E on mice irradiated by sublethal doses

Creators

  • 1. Department of Basic Nuclear Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, Jiangsu Suzhou (China)

Description

To investigate the protective effects of C60(OH)24-SLN-E on mice exposed to sub-lethal doses of 60Co γ radiation. SPF ICR mice (male) were given C60(OH)24-SLN-E intraperitoneally (i.p.) continuously for 7 days before whole-body 60Co γ radiation. The total doses were 6.0 Gy and the dose rate was 0.42 Gy/min. The survival situation, the change of body weight and peripheral blood cell on the 14th day after sub-lethal doses of 60Co γ irradiation were observed. C60(OH))24-SLN-E pretreated before IR could effectively reduce the decrease of body weight and peripheral blood leukocyte in mice induced by 60Co γ radiation, it could also enhance the recovery of hematopoiesis of red bone marrow after irradiation, which had statistical significance compared with the irradiation group (p < 0.05). C60(OH)24-SLN-E has efficient capacity of radioprotection in mice exposed to sub-lethal doses of 60Co γ radiation. (authors)

Additional details

Publishing Information

Journal Title
Radiation Protection (Taiyuan)
Journal Volume
35
Journal Issue
5
Journal Page Range
p. 284-288
ISSN
1000-8187

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
51053319
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD FORMATION; BONE MARROW; COBALT 60; COMPARATIVE EVALUATIONS; DOSE RATES; GAMMA RADIATION; IRRADIATION; LETHAL DOSES; LEUKOCYTES; MICE; NANOMATERIALS; RADIATION INJURIES; RADIATION PROTECTION
Descriptors DEC
ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; COBALT ISOTOPES; DISEASES; DOSES; ELECTROMAGNETIC RADIATION; EVALUATION; HEMATOPOIETIC SYSTEM; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
4 figs., 1 tab., 7 refs.