Published July 1989 | Version v1
Journal article Metadata-only

Effect of gallium nitrate on the in vivo distribution of 67Ga in rats bearing inflammatory lesions

Creators

  • 1. Tohoku Coll. of Pharmacy, Sendai (Japan)

Description

Effect of gallium nitrate on the pharmacokinetics and tissue accumulation of 67Ga was investigated in rats bearing turpentine oil-induced abscess. Gallium nitrate accelerated the blood disappearance of 67Ga, but this effect was less potent than that of ferric nitrate. The accumulation of 67Ga in liver was significantly lowered by gallium nitrate, but no significant decrease of 67Ga accumulation in abscess was observed. On the other hand, 67Ga accumulation in bone was slightly facilitated by gallium nitrate. Ferric nitrate exerted a similar effect on tissue accumulation of 67Ga as gallium nitrate. (author)

Additional details

Publishing Information

Journal Title
Radioisotopes (Tokyo)
Journal Volume
38
Journal Issue
7
Series
Radioisotopes (Tokyo).
Journal Page Range
311-314
ISSN
0033-8303
CODEN
RAISA

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
21006043
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BLOOD; BONE TISSUES; GALLIUM NITRATES; GALLIUM 67; IN VIVO; INFLAMMATION; IRON NITRATES; KIDNEYS; LIVER; MUSCLES; RADIONUCLIDE KINETICS; RATS; TISSUE DISTRIBUTION; TURPENTINE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CONNECTIVE TISSUE; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; GALLIUM COMPOUNDS; GALLIUM ISOTOPES; GLANDS; INTERMEDIATE MASS NUCLEI; IRON COMPOUNDS; ISOTOPES; KINETICS; MAMMALS; MATERIALS; NITRATES; NITROGEN COMPOUNDS; NONAQUEOUS SOLVENTS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; ORGANS; OXYGEN COMPOUNDS; PATHOLOGICAL CHANGES; RADIOISOTOPES; RODENTS; SOLVENTS; TERPENES; TISSUES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES