Published July 2017 | Version v1
Journal article Metadata-only

A practical guide to amyloid PET reading and interpretation

Creators

  • 1. Division of nuclear medicine, Nantes university hospital, Nantes (France)
  • 2. Division of nuclear medicine and molecular imaging, Geneva university hospitals, rue Gabrielle-Perret-Gentil 4, 1211 Geneva (Switzerland)
  • 3. LANVIE, faculty of medicine, Geneva university, Geneva (Switzerland)
  • 4. NIMTlab, faculty of medicine, Geneva university, Geneva (Switzerland)

Description

The extracellular deposits of beta-amyloid are one of the histological lesions required for the neuropathological diagnosis of Alzheimer's disease. During the last decade, various PET tracers have been validated and have market authorization for the visualisation in vivo of amyloid plaques, with excellent sensitivity and specificity. The aim of this paper is to provide a practical guide for the visual read and interpretation of this image modality and to discuss its most recent developments for the integration in the diagnostic process and in patient management. (authors)

Availability note (English)

Available from doi: http://dx.doi.org/10.1016/j.mednuc.2017.06.008

Abstract (French)

Les depots extracellulaires de peptides beta-amyloides constituent une des lesions histologiques necessaires pour le diagnostic neuropathologique de la maladie d'Alzheimer. Pendant la derniere decennie, plusieurs traceurs PET ont ete valides et ont maintenant une autorisation de mise sur le marche pour visualiser les plaques amyloides in vivo, avec des sensibilite et specificite excellentes. L'objectif de cet article est de fournir un guide pratique a la lecture et a l'interpretation de ces images, ainsi que de decrire les perspectives de developpement plus recentes ouvertes par cette modalite pour son integration dans le processus diagnostique et la prise en charge des patients. (auteurs)

Additional details

Additional titles

Original title (French)
Guide a la lecture et interpretation de l'imagerie PET des plaques amyloides

Identifiers

DOI
10.1016/j.mednuc.2017.06.008;

Publishing Information

Journal Title
Medecine Nucleaire. Imagerie Fonctionnelle et Metabolique
Journal Volume
41
Journal Issue
no.4
Journal Page Range
p. 299-306
ISSN
0928-1258
CODEN
MNIMEX

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
53085858
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
DIAGNOSIS; IMAGES; IN VIVO; MARKET; NERVOUS SYSTEM DISEASES; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; SENSITIVITY; SPECIFICITY
Descriptors DEC
COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; TOMOGRAPHY

Optional Information

Notes
24 refs.