Intense, diffuse hepatic and splenic uptake in ^99mTc methylene diphosphonate (MDP) scintigraphy

Serial cases ^99mTc methylene diphosphonate (MDP) scintigraphy incidentally revealed intense, diffuse hepatic and splenic uptake in our center. On occasion, there is incidental detection of soft-tissue uptake may be considered because of different causes. Following some sequences day, the hepatic - splenic uptake persisted in patients who have not any benign/malignant hepatic-splenic lesions on conventional modalities. There are several reasons to describe the mechanism of extra osseous uptake on skeletal scintigraphy. This paper reviews the scintigraphic features of hepatic-splenic uptake and discuss possible reasons for such uptake in practice. (author)