The application of γ-scintigraphy for the evaluation of the relative spreading of suppository bases in rectal hard gelatin capsules

The relative spreading of suppository base and incorporated suspension in the rectum of human subjects has been followed using the technique of γ-scintigraphy. Suppositories formulated from a surfactant system, Labrafil WL2514, and a standard triglyceride base, Witepsol H15, did not spread to a particularly great extent. When spreading did occur the movement of the base did not necessarily lead to a similar spreading of the suspended material. Such separation of suspended material from the base was greater for the surfactant system than for the simple triglyceride system. 10 refs.; 8 figs