Published September 2021 | Version v1
Journal article Metadata-only

Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo

Creators

  • 1. Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education & School of Life Science and Technology, Xidian University, Xi'an, Shaanxi (China)
  • 2. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire (United States)
  • 3. Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire (United States)
  • 4. Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire (United States)
  • 5. Department of Chemistry, School or Arts and Sciences, University of Pennsylvania, Philadelphia (United States)
  • 6. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (United States)

Description

Delivery of radiation at ultrahigh dose rates (UHDRs), known as FLASH, has recently been shown to preferentially spare normal tissues from radiation damage compared with tumor tissues. However, the underlying mechanism of this phenomenon remains unknown, with one of the most widely considered hypotheses being that the effect is related to substantial oxygen depletion upon FLASH, thereby altering the radiochemical damage during irradiation, leading to different radiation responses of normal and tumor cells. Testing of this hypothesis would be advanced by direct measurement of tissue oxygen in vivo during and after FLASH irradiation.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.ijrobp.2021.03.056

Additional details

Identifiers

DOI
10.1016/j.ijrobp.2021.03.056;
PII
S0360301621003588;

Publishing Information

Journal Title
International Journal of Radiation Oncology, Biology and Physics
Journal Volume
111
Journal Issue
1
Journal Page Range
p. 240-248
ISSN
0360-3016
CODEN
IOBPD3

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53122348
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANIMAL TISSUES; BIOLOGICAL RADIATION EFFECTS; DOSE RATES; HYPOTHESIS; IN VITRO; IN VIVO; IRRADIATION; NEOPLASMS; RADIOCHEMISTRY; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; BIOLOGICAL EFFECTS; BODY; CHEMISTRY; DISEASES; RADIATION EFFECTS

Optional Information

Notes
Published by Elsevier Inc.