Comparative Study Between 99mTc-Kanamycin And 99mTc-Gentamicin As Diagnostic Agents For Bacterial Infection

Kanamycin and gentamicin are aminoglycosides antibiotics indispensable in the therapy of acute infections. Labelling with Tc-99m depends on the ligand and reducing agent concentrations, pH and the reaction time. Radiochemical yield and stability were determined by paper and thin layer chromatography. Biodistribution studies of 99mTc-kanamycin and 99mTc-gentamicin were performed in rats. The localization of radioactivity of both complexes in infected sites induced by Staphylococcus aureus indicated the high binding affinity of these drugs. 99mTc-gentamicin has an effective bacterial action against gram positive bacteria S. aureus which confirms the efficacy of this complex as diagnostic agent for bacterial infections.