Detection of spike protein of SARS-CoV-2 by surface enhanced Raman spectroscopy

The development of rapid detection technique with high sensitivity and high veracity for SARS-CoV-2 is of great importance for the prevention and control of epidemic. In this work, the trace spike protein (S protein) of SARS-CoV-2 in human saliva was detected by surface enhanced Raman spectroscopy (SERS) technique. Significant differences can be found between the Raman spectra of the S protein stained saliva sample and the primitive saliva sample. These results will lay the foundation for the future rapid detection of SARS-CoV-2 by SERS technique. (authors)