Published June 1, 1982
| Version v1
Journal article
Low dose radiosensitivity of alloimmune cytotoxic T cells
Creators
- 1. Department of Pathology, University of New Mexico, School of Medicine, Albuquerque
Description
Low dose radiosensitivity of in vitro generated alloimmune murine cytotoxic T lymphocytes (CTL) was studied. It appears that a subset of CTL exists that can be killed with 10-25 rad of x rays. These radiosensitive CTL are Lyt-1,2+ T lymphocytes. Analyses of cytotoxicity by chromium release assays indicate that the radiosensitive CTL are present in responder spleen cell cultures from all strains of mice tested. The generation of these effector cells is most pronounced in animals of the C57BL background. The mechanism of low dose radiosensitivity appears to be interphase death
Additional details
Publishing Information
- Journal Title
- J. Exp. Med.
- Journal Volume
- 155
- Journal Issue
- 6
- Series
- J. Exp. Med.
- Journal Page Range
- 1858-1863
- ISSN
- 0022-1007
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 14761124
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOCHEMICAL REACTION KINETICS; BIOLOGICAL PATHWAYS; BIOLOGICAL RADIATION EFFECTS; CELL CYCLE; CHROMIUM; IMMUNE REACTIONS; IN VITRO; LOW DOSE IRRADIATION; LYMPHOCYTES; MICE; RADIOSENSITIVITY; X RADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ELEMENTS; IONIZING RADIATIONS; IRRADIATION; KINETICS; LEUKOCYTES; MAMMALS; MATERIALS; METALS; RADIATION EFFECTS; RADIATIONS; REACTION KINETICS; RODENTS; SOMATIC CELLS; TRANSITION ELEMENTS; VERTEBRATES