Published August 1989 | Version v1
Journal article Metadata-only

A new bone marrow imaging agent: preparation of 99mTc-polyphase liposomes and its animals experiment

Creators

  • 1. China-Japan Friendship Hospital, Beijing, BJ (China). Cancer Hospital

Description

Here a new bone marrow imaging agent, 99mTc-polyphase liposomes (99mTc-PL) was reported. It was labelled with 99mTc using the stannous chloride method, the labelling rate was over 95% (n = 20). Imaging studies of the bone marrow in rabbits showed that the bone marrow was visulized at 30 min, and was more distinct at 1 ∼ 3.5 h. Tissue distribution of 99mTc-PL in rabbits (n = 9) revealed that the bone marrow uptake rate of 99mTc-PL was greater than bone uptake rate at three time phases (6.6%, 1.5h, 14%, 3.5h, 5%, 24h versus 0.6%, 1.5h, 0,4%, 3.5h, 0.4%, 24h, P < 0.01). Blood clearence rate was 84% at 45 min, and over 98% at 24 hours. This study shown that 99mTc-PL may be useful as a new bone marrow imaging agent

Additional details

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine
Journal Volume
9
Journal Issue
3
Series
Chin. J. Nucl. Med.
Journal Page Range
167-168
ISSN
0253-9780
CODEN
CITCD

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
22018555
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BONE MARROW; CHEMICAL PREPARATION; CLEARANCE; CONTRAST MEDIA; IMAGES; LABELLED COMPOUNDS; LABELLING; LIPOSOMES; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; HEMATOPOIETIC SYSTEM; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SYNTHESIS; TECHNETIUM ISOTOPES; TISSUES; YEARS LIVING RADIOISOTOPES