Published 2010 | Version v1
Miscellaneous Open

Development of a therapeutic radiopharmaceutical 177Lu-DOTA- Minigastrin for potential use in PRRT

Creators

  • 1. Comision Nacional de Energia Atomica (Argentina)
  • 2. Autoridad Regulatoria Nuclear (Argentina)

Description

The aim of this work is to obtain 177Lu-DOTA-Minigastrin with high radiochemical purity (RP) and the highest specific activity (Ae) as possible, using a locally produced (Nuclear Reactor RA-3, Ezeiza Atomic Center) 177LuCl3 of an intermediate level of Ae (between 6.36 to 17.95 Ci/mg of 176Lu) ) and also to perform in vitro and in vivo stability tests, dose calculation in normal mice and its extrapolation to a human model. (authors)

Abstract (Spanish)

El objetivo de este trabajo consistio en obtener 177Lu-DOTA-Minigastrina con una alta pureza radioquimica (PR) y la mayor actividad especifica (Ae) posible, empleando 177LuCl3 de media Ae (entre 6,36-17,95 Ci/mg de 176Lu) de produccion local (Reactor Nuclear RA-3, Centro Atomico Ezeiza), y realizar los ensayos de estabilidad in vitro e in vivo, el calculo de dosis en ratones normales y su extrapolacion a un modelo humano. (autores)

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Part of:
Technical Memory 2010. Nuclear Regulatory Authority

Additional details

Additional titles

Original title (Spanish)
Desarrollo de un radiofarmaco terapeutico

Identifiers

URL
http://www.arn.gob.ar/images/stories/informes_y_documentos/memoria_tecnica/MT_2010/mt15_10_puerta_yepes.pdf;

Publishing Information

Publisher
ARN
Imprint Place
Buenos Aires (Argentina)
Imprint Title
Technical Memory 2010. Nuclear Regulatory Authority
Imprint Pagination
228 p.
Journal Page Range
p. 123-140
Report number
INIS-AR-A--14

Conference

Title
Annual Price 'Florencio Fiorini' from the Florencio Fiorini Foundation and the University of Salvador
Dates
2010
Place
Buenos Aires (Argentina)

INIS

Country of Publication
Argentina
Country of Input or Organization
Argentina
INIS RN
44096787
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S61: RADIATION PROTECTION AND DOSIMETRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
EXTRAPOLATION; IN VITRO; IN VIVO; LUTETIUM 177; MICE; NUCLEAR MEDICINE; RADIATION DOSES; RADIOPHARMACEUTICALS
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DOSES; DRUGS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUTETIUM ISOTOPES; MAMMALS; MATERIALS; MATHEMATICAL SOLUTIONS; MEDICINE; NUCLEI; NUMERICAL SOLUTION; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI; RODENTS; VERTEBRATES

Optional Information

Notes
13 refs., 13 figs., 5 tabs. Imprint:Memoria Tecnica 2010. Autoridad Regulatoria Nuclear