Published July 1986
| Version v1
Journal article
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799
Creators
- 1. Mount Vernon Hospital, Middlesex, England
Description
Misonidazole, SR-2508 and Ro 03-8799 have been given in sequence to patients before tumor sampling. Tumor concentrations of the three drugs have been measured and it has been possible to make prediction as to the likely advantage of the newer drugs over misonidazole. Based upon the three cases described here and 13 others given two drug combination, we suggest that in multifraction radiotherapy, both are likely to prove more than five times more efficient than misonidazole
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Issue
- no.7
- Series
- Int. J. Radiat. Oncol., Biol. Phys.
- ISSN
- 0360-3016
- CODEN
- IOBPD
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18018865
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- EFFICIENCY; MISONIDAZOLE; NEOPLASMS; PATIENTS; RADIOSENSITIZERS; RADIOTHERAPY; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; DISEASES; DISTRIBUTION; DRUGS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; MEDICINE; NITRO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RESPONSE MODIFYING FACTORS; THERAPY