Experimental studies on tissue distribution of 14C-labelled anitimicrobic drugs in otorhinolaryngological field

The distribution and concentration of antimicrobic drugs in the otorhinolaryngological field was studied together in the excised tissue by freezing macro-autoradiography in rabbits. Of the three Nalidixic acid antimicrobic analogues, i.e., pipemidic acid, AM-715 and rosoxacine, the first two accumulated remarkably in the soft palate, showing affinity for the cartilage. The concentrations of the three drugs in the paranasal sinus were higher on the medial portion of the maxilla than on the lateral portion, and the order of concentrations for ethmoidsinus were the lateral > anterior > posterior > medial portions. The present technique was thought to be a useful means for clarifying the distribution of drugs in vivo. (Chiba, N.)