Radiogenic lesions as a concomitant reaction in radiotherapy. Synopsis of clinical results and cases described in literature exemplified by means of selected organ systems

The results of recent clinical studies are presented systematically which appear to have a practical relevance for an assessment of radio therapy: A given indication is juxtaposed to a contraindication in order to be able to assess the healing chances of the primary disease with the foreseeable complications of radiotherapy before hand and to help reduce radiogenic concomitant noxae as much as possible. Macroscopic findings are concentrated on owing to their clinical importance. Presentation of those radiation effects is focussed on which occured after treatment of malignant tumours involving orthovolt X-ray, gamma-ray and MeV irradiation as well as telecobalt and telecesium. Post irradiation reaction are dealt with by means of selected organ systems. A separate section deals with teratogenic and genetic radiation noxae. Type and dimension of early and delayed reactions in each organ are described and the most important parameters of the treatment involved (Espec. applied dose and conditions of possible fractionation) are given which resulted in the radiation effects concerned. (orig./MG)