Published 1988
| Version v1
Journal article
Streptomycin and N-methyl-N'-nitro-N-nitrosoguanidine inhibit incorporation of 14C-precursors of macromolecule synthesis in Euglena gracilis
Description
Streptomycin and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) cause a 100% hereditary bleaching of Euglena gracilis. In spite of the outcome being the same, the corresponding mechanisms differ. By investigating the incorporation of 14C-labelled precursors of macromolecule synthesis, streptomycin was shown to inhibit the synthesis of nucleic acids and proteins to the same extent (56%) whereas in the case of MNNG a 66% inhibition of nucleic acid synthesis and a 24% inhibition of protein synthesis were observed. (author). 3 figs., 3 tabs., 13 refs
Additional details
Publishing Information
- Journal Title
- Folia Microbiologica (Prague)
- Journal Volume
- 33
- Journal Issue
- 6
- Series
- Folia Microbiol. (Prague).
- Journal Page Range
- 466-473
- ISSN
- 0015-5632
- CODEN
- FOMIA
INIS
- Country of Publication
- Czech Republic
- Country of Input or Organization
- Serbia and Montenegro
- INIS RN
- 20056089
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ADENINES; BIOSYNTHESIS; CARBON 14 COMPOUNDS; CHLOROPLASTS; EUGLENA; GROWTH; GUANIDINES; INHIBITION; LEUCINE; NITROSO COMPOUNDS; NUCLEIC ACIDS; PLANT CELLS; PRECURSOR; PROTEINS; STREPTOMYCIN; UPTAKE
- Descriptors DEC
- ALGAE; AMINES; AMINO ACIDS; ANTIBIOTICS; ANTIMETABOLITES; CARBON COMPOUNDS; CARBONIC ACID DERIVATIVES; CARBOXYLIC ACIDS; CELL CONSTITUENTS; DRUGS; HETEROCYCLIC COMPOUNDS; MICROORGANISMS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; PURINES; SYNTHESIS; UNICELLULAR ALGAE