Published October 1986 | Version v1
Journal article Metadata-only

In vivo evaluation of radioiodinated spiroperidol derivatives as radiopharmaceutical for dopamine receptor study

Creators

  • 1. Kyoto Univ. (Japan). Faculty of Medicine
  • 2. Kyoto Univ. (Japan). Faculty of Pharmaceutical Science
  • 3. Sumitomo Chemical Co. Ltd., Takarazuka (Japan). Research Center

Description

Among various iodinated butyrophenones synthesized, 2'-iodospiroperidol (2'-ISP) has shown in vitro, high binding affinity for cerebral striatal dopamine receptors. Biodistribution of 2'-ISP in various regions of the mouse brain was screened by comparative studies with the iodinated derivatives 4-iodospiroperidol(4-ISP) and 4'-iodospiroperidol(4'-ISP). (author)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
23
Journal Issue
10-12
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1323-1324
ISSN
0362-4803
CODEN
JLCRD

Conference

Title
6. international symposium on radiopharmaceutical chemistry.
Dates
29 Jun - 3 Jul 1986.
Place
Boston, MA (USA).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18082046
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
AROMATICS; BRAIN; DOPAMINE; IODINE 125; MICE; ORGANIC NITROGEN COMPOUNDS; RADIOPHARMACEUTICALS; RECEPTORS; TISSUE DISTRIBUTION
Descriptors DEC
AMINES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; STEROIDS; SYMPATHOMIMETICS; VERTEBRATES