Fully automated synthesis of O-(2-18F-fluoroethyl)-L-tyrosine

18F- is produced via nuclear reaction 18O(p, n)18F at PET trace Cyclotron. O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) is synthesized by a two-step reaction at FDG MicroLab Synthesis. Nucleophilic fluorination reaction of 18F-fluoride with 1,2-di(4-methyphenylsulfonyloxy) ethane on column give 2-18F-1-(4-methylphenylsulfonyloxy) ethane, and 18F-fluoroalkylation of L-tyrosine di-sodium salt with 2-18F-1-(4-methylsulfonyloxy) ethane formed 18F-FET. The overall radiochemical yield with no decay correction is more than 4%, the whole synthesis time is about 52 min, and the radiochemical purity is above 95%. The synthetic 18F-FET can be suitable for clinical study with PET imaging