Published May 1988
| Version v1
Journal article
Persistent dose-dependent increases in cycling of haemopoietic precursor cells after irradiation
Creators
- 1. Christie Hospital and Holt Radium Inst., Manchester (UK). Paterson Labs.
Description
Between 3 weeks and 36 months after irradiation of mice, there was a dose-dependent increased level of cycling in haemopoietic stem cells (CFU-S) and in granulocyte-macrophage precursor cells (GM-CFC). For CFU-S the percentage kill measured using the thymidine suicide technique increased from about 10% in controls to a high and persistent average level of about 45% after 10 Gy γ-rays, and for GM-CFC the increase was from about 30% to about 50%. (author)
Additional details
Publishing Information
- Journal Title
- Cell and Tissue Kinetics
- Journal Volume
- 21
- Journal Issue
- 3
- Series
- Cell Tissue Kinet.
- Journal Page Range
- 201-204
- ISSN
- 0008-8730
- CODEN
- CTKIA
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 21013940
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BLOOD CELLS; CFU; DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; HEMATOPOIETIC SYSTEM; MICE; PRECURSOR; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MATERIALS; RADIATION EFFECTS; RADIATIONS; RODENTS; VERTEBRATES