Studies in radiosensitizing effects of misonidazole and SR-2508 on C3H/He mouse mammary tumors
Creators
- 1. Kyoto Univ. (Japan). Faculty of Medicine
Description
The radiosensitizing efficacy of SR-2508, a new 2-nitroimidazole, which is less neurotoxic than misonidazole (MISO) was studied using transplantable mammary carcinoma of C3H/He mice. Tumor responses to treatments were evaluated by growth-delay time assay. In single irradiations, the enhancement ratios of 0.5 mmole/kg of MISO and 1.5 mmole/kg of SR-2508, which were equitoxic to C3H/He mice, were 1.42 and 1.84 respectively. In fractionated irradiations with three fractions over two days or five fractions over four days, the enhancement ratios of 1.5 mmole/kg of SR-2508 were 1.40 and 1.34 respectively. On the other hand the enhancement ratios of MISO at the above mentioned dose in respective fractionated irradiations were 1.15 or 1.11. SR-2508 is considered promising as a hypoxic cell radiosensitizer for clinical use. (author)
Additional details
Publishing Information
- Journal Title
- Radiat. Med.
- Journal Volume
- 2
- Journal Issue
- 1
- Series
- Radiat. Med.
- Journal Page Range
- 71-75
- ISSN
- 0288-2043
- CODEN
- RAMEE
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 18018273
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- COMPARATIVE EVALUATIONS; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL NEOPLASMS; FRACTIONATED IRRADIATION; GROWTH; IMIDAZOLES; INHIBITION; MICE; RADIOSENSITIVITY; X RADIATION
- Descriptors DEC
- ANIMALS; AZOLES; DISEASES; ELECTROMAGNETIC RADIATION; EVALUATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIATIONS; RODENTS; VERTEBRATES