Published November 1993
| Version v1
Journal article
Synthesis of α-[14C]methyl and α[3H]methyl-L-tryptophan
Description
The title compounds were synthesized starting from dimethyl (2S,3aR,8aS)-(+)-8-(phenylsulfonyl)hexahydropyrrolo[2,3-b]indole-1 ,2-dica rboxylate. This compound on treatment with LDA followed by reaction with [14C]methyl iodide or [3H]methyl iodide gave the methyl substituted derivative which on treatment with trifloroacetic acid followed by hydrolysis with alkali gave the desire alpha-[14C]methyl-or [3H]methyl-L-tryptophan, respectively, in 50-60% radiochemical yield. (Author)
Additional details
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 33
- Journal Issue
- 11
- Journal Page Range
- p. 1029-1038.
- ISSN
- 0362-4803
- CODEN
- JLCRD4
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 25033221
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; SEROTONIN; TRITIUM COMPOUNDS; TRYPTOPHAN
- Descriptors DEC
- AMINES; AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZOLES; CARBON COMPOUNDS; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DRUGS; EMISSION COMPUTED TOMOGRAPHY; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; LABELLED COMPOUNDS; MATERIALS; NEUROREGULATORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOACTIVE MATERIALS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SYMPATHOMIMETICS; SYNTHESIS; TOMOGRAPHY; TRYPTAMINES