Published August 1, 2008
| Version v1
Journal article
Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligand
Creators
- 1. Basic Research Activities of Innovative Biosciences, Tokyo 105-0001 (Japan)
- 2. Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497 (Japan)
- 3. Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 (Japan)
- 4. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Kyuban-cho, Koshien, Nishinomiya, Hyogo 663-8179 (Japan)
Description
In the course of an effort to identify novel agonists of the farnesoid X receptor (FXR), coumestrol was determined to be one such ligand. Reporter and in vitro coactivator interaction assays revealed that coumestrol bound and activated FXR. Treatment of Hep G2 cells with coumestrol stimulated the expression of FXR target genes, thereby regulating the expression of target genes of the liver X receptor and hepatocyte nuclear factor-4α. Through these actions, coumestrol is expected to exert beneficial effects on lipid and glucose metabolism
Availability note (English)
Available from http://dx.doi.org/10.1016/j.bbrc.2008.04.136Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2008.04.136;
- PII
- S0006-291X(08)00842-5;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 372
- Journal Issue
- 3
- Journal Page Range
- p. 395-399
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 40023701
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ALKALINE PHOSPHATASE; ATP; CHOLIC ACID; DMSO; ENZYME IMMUNOASSAY; ESTROGENS; GLUCOSE; GLUTATHIONE; IN VITRO; LIGANDS; LIVER; METABOLISM; PHOSPHOENOLPYRUVATE; PHOSPHOLIPIDS; POLYMERASE CHAIN REACTION; RECEPTORS; TRANSCRIPTION; TRIGLYCERIDES
- Descriptors DEC
- ALDEHYDES; BILE ACIDS; BIOASSAY; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; DRUGS; ENZYMES; ESTERASES; ESTERS; GENE AMPLIFICATION; GLANDS; HEXOSES; HORMONES; HYDROLASES; HYDROXY COMPOUNDS; IMMUNOASSAY; LIPIDS; MEMBRANE PROTEINS; MONOSACCHARIDES; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PEPTIDES; PHOSPHATASES; POLYPEPTIDES; PROTEINS; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SACCHARIDES; STEROID HORMONES; STEROIDS; STEROLS; SULFOXIDES
Optional Information
- Copyright
- Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.