Computational study for mechanisms of radiation protection effects of Xuebijing

Objective: To explore the related mechanisms of Xuebijing anti-radiation effects. Methods: The chemical molecules in Xuebijing were docked into four blood coagulation targets: thrombin, plasminogen activator inhibitor type 1, thromboxane A2 receptor and blood coagulation factor Ⅸa by molecular docking technology respectively, and then the docking results were analyzed and the effect of the mechanisms was evaluated. Results: The chemical molecules in Xuebijing had interactions with all four blood coagulation targets, especially for thrombin. Conclusion: The related mechanism of Xuebijing anti-radiation effect is probably resulted from the antagonism effect towards blood coagulation targets. (authors)