Published July 2006 | Version v1
Journal article Metadata-only

Basic experimental study on boron neutron capture therapy

Creators

  • 1. Hebei Univ. of Technology, Tianjin (China). School of Science
  • 2. China Inst. of Atomic Energy, Beijing (China)
  • 3. Beijing Normal Univ., Beijing (China). Key Laboratory of Beam Technology and Modification of Ministry of Education

Description

α particles and 7Li ions are produced by radionuclide 241Am and the HI-13 tandem accelerator respectively to simulate productions of BNCT (Boron Neutron Capture Therapy). DNA solution is irradiated by the above rays in air firstly, and then the DNA fragments are analyzed by AFM (Atomic Force Microscopy). The software ImageJ is used to measure the length of DNA fragments. Lastly, the experimental data of DNA fragments and DNA configuration are obtained. The results show that the mean length of DNA fragments increase as dose decreases; the fraction of linear and open circle DNA molecules increase as dose decreases; lithium particles cause more strong relative biological effects than α particles. (authors)

Additional details

Publishing Information

Journal Title
Atomic Energy Science and Technology
Journal Volume
40
Journal Issue
4
Journal Page Range
p. 391-395
ISSN
1000-6931

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
38057019
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
ALPHA PARTICLES; AMERICIUM 241; ATOMIC FORCE MICROSCOPY; BIOLOGICAL EFFECTS; BORON; CARCINOMAS; CONFIGURATION; DNA; DNA DAMAGES; DOSE-RESPONSE RELATIONSHIPS; EXPERIMENTAL DATA; I CODES; IRRADIATION; LITHIUM 7; NEUTRON CAPTURE THERAPY; TANDEM ELECTROSTATIC ACCELERATORS
Descriptors DEC
ACCELERATORS; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMERICIUM ISOTOPES; CHARGED PARTICLES; COMPUTER CODES; DATA; DISEASES; ELECTROSTATIC ACCELERATORS; ELEMENTS; HEAVY NUCLEI; INFORMATION; IONIZING RADIATIONS; ISOTOPES; LIGHT NUCLEI; LITHIUM ISOTOPES; MEDICINE; MICROSCOPY; NEOPLASMS; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEI; NUCLEIC ACIDS; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATIONS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; SEMIMETALS; SPONTANEOUS FISSION RADIOISOTOPES; STABLE ISOTOPES; THERAPY; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
5 figs., 17 refs.