Published May 1975
| Version v1
Journal article
Ultraviolet carcinogenesis
Description
A theory of uv carcinogenesis is described in which damage to DNA in the form of pyrimidine dimers occurs in a critical operator region of the genome that controls the synthesis of divisional proteins. There is a chance that a mutation will occur in the region of the operator either during replication or during postreplication repair, so that unchecked growth will be passed on to daughter cells. Comparison with the experiments of Hart and Setlow (1973) indicates that agreement is semiquantitative. (U.S.)
Additional details
Identifiers
Publishing Information
- Journal Title
- International Journal of Quantum Chemistry
- Journal Volume
- 9
- Journal Issue
- 3
- Series
- Int. J. Quant. Chem.
- Journal Page Range
- 473-478
- ISSN
- 0020-7608
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 7223502
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BIOSYNTHESIS; CARCINOGENESIS; DIMERS; DNA; GENOME MUTATIONS; PROTEINS; PYRIMIDINES; RADIATION EFFECTS; ULTRAVIOLET RADIATION
- Descriptors DEC
- AZINES; BIOLOGICAL EFFECTS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; MUTATIONS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOGENESIS; RADIATIONS; SYNTHESIS
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent