Clinical investigations of radiosensitizing action of metronidazole in patients with cancer of the uterine body

The local use of MZ solved in DMSO makes it possible to reach high MZ concentrations (by order 6000-8000 μ g/g) in tumor tissue without a toxic effect of the drug. The results of investigation of radiation pathomorphosis show that the local use of MZ solved in DMSO enhances the damaging effect of radiation on a tumor. Some traits revealed in MZ diffusion (a raised concentration at the serous membrane) must undoubtedly lead to increased efficacy of radiation exposure in zones, reponsible for local therapeutic failures. It will permit a considerable increase in the efficacy of radiation therapy of patients with cancer of the uterine body