Published 1985 | Version v1
Book Metadata-only

Antagonistic effects of manganese on cadmium cytotoxicity

Creators

  • 1. Justus-Liebig-Universitat Giessen, Giessen

Description

The interactions between MnCl2 and CdCl2 were studied in the following cell lines: human embryonic fibroblasts FH, human portio carcinoma line HeLa, Chinese hamster peritoneal cells B14F28, and L-A, a subline of L 929 mouse fibroblasts. In all cells studies Mn protects against Cd effects on proliferation, viability, LDH release, and lactic acid production. With increasing atomic ratio of Mn: Cd the protection is enhanced. Cadmium uptake of cells incubated with 115mCd-labeled CdCl2 decreases significantly in the presence of MnCl2. Thus the protective effect of Mn on Cd cytotoxicity is to a great part due to the inhibition of cellular Cd uptake

Additional details

Publishing Information

Publisher
University of Missouri Extension Information.
Imprint Place
Columbia, MO (USA)
Imprint Title
Trace substances in environmental health-XIX
Imprint Pagination
vp.
Journal Page Range
p. 228-237.

Conference

Title
19. annual conference on trace substances in environmental health.
Dates
3-6 Jun 1985.
Place
Columbia, MO (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
21019317
Subject category
S61: RADIATION PROTECTION AND DOSIMETRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL EFFECTS; CADMIUM CHLORIDES; CADMIUM 115; CELL CULTURES; CELL PROLIFERATION; EMBRYONIC CELLS; FIBROBLASTS; HAMSTERS; HELA CELLS; MANGANESE CHLORIDES; TRACER TECHNIQUES
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CADMIUM COMPOUNDS; CADMIUM HALIDES; CADMIUM ISOTOPES; CHLORIDES; CHLORINE COMPOUNDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HALIDES; HALOGEN COMPOUNDS; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; MANGANESE COMPOUNDS; NUCLEI; RADIOISOTOPES; RODENTS; SOMATIC CELLS; TRANSITION ELEMENT COMPOUNDS; TUMOR CELLS; VERTEBRATES

Optional Information

Secondary number(s)
CONF-8506299--.