Published June 1988 | Version v1
Journal article Metadata-only

Synthesis of deuterium-labelled viloxazine

Creators

  • 1. Tokyo Coll. of Pharmacy (Japan)

Description

The synthesis of deuterium-labelled viloxazine with high isotopic purity is described. The synthetic procedures employ alkylation of 2-(benzyloxy)phenol with [2H5]ethyl iodide for the introduction of deuterium. Catalytic removal of the benzyl group of the deuterated product followed by reaction with epichlorohydrin afforded 1,2-epoxy-3-(2'-pentadeuteroethoxy-phenoxy)propane. Addition of 2-aminoethyl hydrogen sulphate to the epoxide and subsequent ring formation into a morpholine derivative produced the desired [2H5]viloxazine. (author)

Additional details

Additional titles

Augmented title (English)
Antidepressant

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
25
Journal Issue
6
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
661-665
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
20007579
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ALKYLATION; ANTIDEPRESSANTS; CHEMICAL PREPARATION; DEUTERIUM COMPOUNDS; LABELLING; MORPHOLINES; RADIOPHARMACEUTICALS
Descriptors DEC
AMINES; CENTRAL NERVOUS SYSTEM AGENTS; CHEMICAL REACTIONS; DRUGS; ETHERS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PSYCHOTROPIC DRUGS; RADIOACTIVE MATERIALS; SYNTHESIS