Aggravation of Irradiation Induced Impairment in Protein Metabolism in Albino Rate Subjected to Oral Injection of Kelthane Miticide

The combined effect of both whole body gamma radiation exposure and administration of organo chlorine miticide kelthaneon protein metabolism was investigated in male albino rats. Kelthane was orally given at a dose level of 100 mg/kg body weight over a period of seven days. Irradiation process permitted the rats to receive one Gray every other day at a weekly cumulative dose of 3 Gy up to a total dose of 15 Gy. The biochemical assays included total proteins, protein fractions, free amino acids (FAAS) and urea level in blood serum as well as protein content and its FAAS in urine . The data revealed significant changes in the protein parameters due to whole body gamma irradiation. These changes were shown to be dose and time dependent which reached their maximum at the end of the experimentation period. The alterations were more pronounced in animal groups exposed to gamma radiation and received keltane pesticide