Gamma rays application in veterinary immunology

Full text: The process based on stimulated action of ionized radiation, change of quality of agricultural goods and row materials, biocides including bactericide action of ionized radiation are among the methods of radiation biotechnology, which can be applied in agriculture. We used the bactericide action of ionized radiation in technological process for creation of fundamentally new preparation possessed by by immunogenic properties and named as 'radio vaccine'. This term is well known and frequently used in scientific papers in the field of applied radiobiology. It is well known that physical (thermal) and chemical actions are used for preparation of vaccine for veterinary. It was noted that this process resulted in destruction of antigenic structure of bacteria cells, with are responsible for immunity creation. The possibility of virulence reduction at constant immunogenic properties of microorganism and keeping its antigenic structure can be achieved by using ionized radiation as one of the factor, which influences on bacteria. Taking into account the necessity of vaccine improvement and increase of quantity of associated vaccine one of the most important problems of veterinary science and particle is creation of vaccines of new generation which are characterized by the ability to form immunity against several diseases of agricultural animals. As a result of many-years investigations using gamma rays radiations in UzSRIV (laboratory of radiobiology) the radiation biotechnology of vaccine preparation was developed. These vaccines are necessary for practical application. Radiation biotechnology allows to prepare high-effective mono-, associated and polyvalent radio vaccines against widespread infection diseases of agricultural animals especially cubs (calves, lambs, young pigs). On the basis of developed radiation biotechnology there were prepared the following vaccines: 'Associated radio vaccine against colibacteriosis and salmonellosis of small horned cattle', 'Associated radio vaccine against colibacteriosis and salmonellosis of calves', 'Polyvalent vaccine against pasteurellesis, colibacteriosis and salmonellosis of agricultural animals'. The results of investigations showed that using smaller dosage and divisible use the prepared radio vaccines provide immunity performance allowing to protect animals from the diseases during one year. The research documents (Technical specifications, Instruction on preparation and control, Instruction on application) which were approved in 2004 by General State Administration of veterinary of Republic of Uzbekistan have been submitted on associated and polyvalent radio vaccines. Mentioned above radio vaccines are of great interest and widely used in veterinary practice in Uzbekistan. More than 1 million small horned cattle and calves were vaccinated last years. It is perspective the widening of radio vaccines supply in republics of Central Asia. The temporal patent for one vaccine and positive decision for another one were taken out by Patent Department of Republic of Uzbekistan