Iopentol in urography

The safety and diagnostic efficacy of iopentol 300 mg I/ml were compared with iohexol 300 mg I/ml in 300 patients submitted for urography. The study was carried out as a double-blind, randomized parallel study. The groups were considered equal with regard to demographic parameters, rate of injection or total dose of injected CM. No changes in blood pressure and no clinically important changes in heart rate were detected in the two groups. No serious adverse events occurred. Seven patients (5%) in the iohexol and 12 patients (8%) in the iopentol group experienced adverse events other than sensation of heat. Fourteen iohexol patients (9%) and 18 iopentol patients (12%) experienced heat related to the CM injection. Excellent films were obtained in most patients and no difference in diagnostic quality between iopentol and iohexol was observed. (author). 11 refs.; 3 tabs