Published March 2013 | Version v1
Journal article Metadata-only

Inhibitory effect of 12C6+ ion and X-ray on angiogenesis in HMEC-1

Creators

  • 1. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Gansu Province, Lanzhou (China)
  • 2. Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou (China)
  • 3. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou (China)
  • 4. University of Chinese Academy of Sciences, Beijing (China)

Description

The study aims to explore the effect of 12C6+ ion and X-ray on proliferation, migration, tube formation and MMPS of human microvascular endothelial cells (HMEC-1). Transwell migration experiment showed that the radiation could inhibit the migration of HMEC-1 in sub-lethal dose 24 h after irradiation. Furthermore, the inhibition ability of 12C6+ ion was stronger than that of X-ray. Matrigel experiment indicated that 12C6+ ion suppressed the tube formation of HMEC-1 spontaneously. However, the inhibitory effect of X-ray had no significance. Meanwhile, Gelatin Zymography showed the expression of MMP-2 was inhibited obviously by 12C6+ ion, while X-ray had little effect on the expression of MMP-2. In conclusion, 12C6+ ion is superior to X-ray in radiotherapy of tumor. (authors)

Additional details

Publishing Information

Journal Title
Nuclear Physics Review
Journal Volume
30
Journal Issue
1
Journal Page Range
p. 84-88
ISSN
1007-4627

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
48083051
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANGIOGENESIS; BLOOD VESSELS; CARBON 12; GELATIN; HEAVY IONS; INHIBITION; IRRADIATION; LETHAL DOSES; MAN; MIGRATION; NEOPLASMS; RADIOTHERAPY; X RADIATION
Descriptors DEC
ANIMALS; BODY; CARBON ISOTOPES; CARDIOVASCULAR SYSTEM; CHARGED PARTICLES; COLLOIDS; DISEASES; DISPERSIONS; DOSES; ELECTROMAGNETIC RADIATION; EVEN-EVEN NUCLEI; IONIZING RADIATIONS; IONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; PROTEINS; RADIATIONS; RADIOLOGY; STABLE ISOTOPES; THERAPY; VERTEBRATES

Optional Information

Notes
5 figs., 15 refs.