Dosimetric feasibility of hypofractionation for metastatic bone/bone marrow lesions from paediatric solid tumours

Highlights: • Iso-effective hypofractionated plans can be generated for most metastatic lesions. • With hypofractionation, similar or less dose in healthy tissues can be achieved. • With overlapping PTV-OAR, increased OAR dose when using less fractions is seen. • Fractionation should be patient-specific depending on the PTV-OAR relationship. • Consensus is needed on dose and fractionation per site, histology and age group. The aim of this study was to determine the feasibility of hypofractionated schedules for metastatic bone/bone marrow lesions in children and to investigate dosimetric differences to the healthy surrounding tissues compared to conventional schedules.