The study of the E838 effect on the augment of radiation treatment in mouse inoculated S180 strain

Objective: To observe E838's activity of restraining tumor growth in mouse and discuss the relative mechanism. Methods: The authors used three different doses of E838 to restrain tumor growth in S180 mouse in one team and the other used 137Cs γ together. Results: In one team, the percent of the E838 (dose: low to high) restraining tumor growth is respectively 49.52%, 54.81%, 53.85%, in the other is respectively 52.12%, 59.62%, 59.62%. Not only the tumor growth of the latter team is slow but the amount of BMNC is high Conclusion: E838 can obviously restrain the tumor growth in s180 mouse and has the radiation augment effect. (authors)