Published November 1975 | Version v1
Journal article Metadata-only

Immunological half-life of porcine proinsulin C-peptide

Creators

  • 1. Kawasaki Medical Coll., Kurashiki (Japan). Div. of Endocrinology
  • 2. Yamaguchi Univ., Ube (Japan). School of Medicine

Description

Immunological half-lifes of injected porcine C-peptide and insulin with RIA were studied and calculated as 9.8 and 8.0 minutes. Higher circulating levels of C-peptide as compared to insulin in normal young swines lead to speculation about a longer half-life of C-peptide. This hypothesis was verified in this study. Immunological half-lifes of porcine proinsulin and insulin in the pig were 20 and 6 minutes, respectively. (GSE)

Abstract (German)

Mit Hilfe von RIA werden die immunologischen Halbwertszeiten von injizierten C-Peptiden und von Insulin in Schweinen bestimmt. Sie betrugen 9,8 respektive 8,0 Min. Hoehere zirkulierende Gehalte von C-Peptiden verglichen zu Insulin lassen vermuten, dass die C-Peptide eine laengere Halbwertszeit aufweisen. Diese Hypothese konnte in vorliegender Studie verifiziert werden. Die immunologischen Halbwertszeiten von Proinsulin und Insulin in Schweinen betragen 20 bzw. 6 Min. (GSE)

Additional details

Identifiers

DOI
10.1055/s-0028-1095679;

Publishing Information

Journal Title
Hormone and Metabolic Research
Journal Volume
7
Journal Issue
06
Series
Horm. Metab. Res.
Journal Page Range
520-521
ISSN
0018-5043

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
7255716
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
AGE DEPENDENCE; BIOLOGICAL HALF-LIFE; INSULIN; LABELLED COMPOUNDS; METABOLISM; PANCREAS; PEPTIDES; RADIOIMMUNOASSAY; REACTION KINETICS; SWINE
Descriptors DEC
ANIMALS; BODY; DIGESTIVE SYSTEM; DOMESTIC ANIMALS; ENDOCRINE GLANDS; GLANDS; HORMONES; ISOTOPE APPLICATIONS; KINETICS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PROTEINS; RADIOACTIVE MATERIALS; TRACER TECHNIQUES; VERTEBRATES

Optional Information

Notes
1 fig.; 4 refs.; Updated automatically by Metadata and Full-Text Enrichment Agent