Published November 1995 | Version v1
Journal article Metadata-only

Differential diagnosis of focal liver lesions by means of MRI and application of the superparamagnetic contrast agent ENDOREM trademark

Creators

  • 1. Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Humboldt Univ., Berlin (Germany)
  • 2. Chirurgische Klinik, Klinikum Rudolf Virchow, Humboldt Univ., Berlin (Germany)

Description

In a phase III/III-B trial the specific contrast enhancement of benign liver tumors, especially FNH and adenoma, versus malignant liver tumors, such as HCC and metastases (colorectal and endocrine tumors) was evaluated using the superparamagnetic iron oxide ENDOREM trademark. The following conclusions were drawn from the results: The use of superparamagnetic iron oxide ENDOREMcircledR allows differentiation of benign and malignant liver tumors on the basis of contrast enhancement, existence and specific enhancement of capsule or scar. In vitro correlation show some limitations of in vivo MRI. (orig./VHE)

Abstract (German)

In einer Phase-III/III-B-Multizenterstudie wurde das spezifische Kontrastmittelenhancement von benignen Lebertumoren, speziell FNH und Adenom, im Gegensatz zu malignen Lebertumoren, wie HCC, Metastasen von kolorektalen Karzinomen und endokrinen Tumoren untersucht. Die Ergebnisse fuehrten zu fogenden Schlussfolgerungen: Die Anwendung des superparamagnetischen Eisenoxids ENDOREM trademark erlaubt die Differenzierung von benignen und malignen Lebertumoren auf der Basis des Kontrastmittelenhancements, der Existenz und des spezifischen Enhancements von Kapsel und Narbe. Die In-vitro-Korrelation ergab Limitationen fuer die In-vivo-MRT. (orig./VHE)

Additional details

Additional titles

Original title (German)
Differentialdiagnose von fokalen Leberlaesionen mittels MRT unter Verwendung des superparamagnetischen Kontrastmittels ENDOREM

Publishing Information

Journal Title
Radiologe
Journal Volume
35
Journal Issue
11,suppl.2
Series
Presented at the ENDOREM symposium on February 18, 25 and on March 25, 1995.
Journal Page Range
p. 258-266.
ISSN
0033-832X
CODEN
RDLGBC

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
27059613
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACCURACY; CONTRAST MEDIA; DIAGNOSTIC USES; LIVER; NEOPLASMS; NMR IMAGING; PATHOLOGICAL CHANGES; SUPERPARAMAGNETISM
Descriptors DEC
BODY; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; GLANDS; MAGNETISM; ORGANS; USES