Published 2012 | Version v1
Journal article Metadata-only

Sesquiterpenes produced by endophytic fungus Phomopsis cassiae with antifungal and acetylcholinesterase inhibition activities

Creators

  • 1. UNESP, Araraquara, SP (Brazil). Inst. de Quimica
  • 2. Universidade Federal de Sergipe (UFS), Aracaju, SE (Brazil). Centro de Ciencias Exatas e Tecnologia
  • 3. Universidade Federal do Mato Grosso (UFMT), Rondonopolis, MT (Brazil). Dept. de Ciencias Biologicas
  • 4. Instituto de Botanica, Sao Paulo, SP (Brazil). Seccao de Fisiologia e Bioquimica de Plantas

Description

Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, including relative stereochemistry, were determined on the basis of detailed interpretation of 2D NMR spectra and comparison with related known compounds. Compounds 1-4 displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as inhibition of acetylcholinesterase. (author)

Availability note (English)

Available from http://www.scielo.br/pdf/qn/v35n11/v35n11a26.pdf

Additional details

Additional titles

Original title (Portuguese)
Sesquiterpenos produzidos pelo fungo endofitico Phomopsis cassiae com atividade antifungica e inibidora de acetilcolinesterase

Identifiers

URL
http://www.scielo.br/pdf/qn/v35n11/v35n11a26.pdf;

Publishing Information

Journal Title
Quimica Nova
Journal Volume
35
Journal Issue
11
Journal Page Range
p. 2233-2236
ISSN
0100-4042

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
44058964
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ACETYLCHOLINE; CARBON 13; CHOLINESTERASE; FUNGI; HYDROGEN 1; INFRARED SPECTRA; LEAVES; LIQUID COLUMN CHROMATOGRAPHY; MAGNESIUM SULFATES; MASS SPECTRA; METABOLITES; METHANOL; NMR SPECTRA; SILICA GEL; STEREOCHEMISTRY; TERPENES
Descriptors DEC
ADSORBENTS; ALCOHOLS; ALKALINE EARTH METAL COMPOUNDS; AMMONIUM COMPOUNDS; AUTONOMIC NERVOUS SYSTEM AGENTS; CARBON ISOTOPES; CARBOXYLESTERASES; CHROMATOGRAPHY; DRUGS; ENZYMES; ESTERASES; ESTERS; EVEN-ODD NUCLEI; HYDROGEN ISOTOPES; HYDROLASES; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; MAGNESIUM COMPOUNDS; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; PARASYMPATHOMIMETICS; PLANTS; PROTEINS; QUATERNARY AMMONIUM COMPOUNDS; SEPARATION PROCESSES; SPECTRA; STABLE ISOTOPES; SULFATES; SULFUR COMPOUNDS