Radiosynthesis of 18F-FMTP
Creators
- 1. Chinese Academy of Sciences, Shanghai (China). Shanghai Inst. of Nuclear Research
Description
3-(4-fluorobenzyl)-8-methoxy-1, 2, 3,4-tetrahydrochromeno[3,4-c]pyridin-5-one (FMTP), a selective D4 receptor antagonist, exhibits nanomolar affinity and high selectivity. 18F-FMTP is synthesized in multistep reactions in which fluorine-18 is introduced by nucleophilic halogen displacement on a quaternary ammonium group precursor. The fluorine-18 labeled intermediate is subsequently reductively aminated with 8-methoxy-1, 2, 3, 4-tetrahydrochromeno[3,4-c]pyridin-5-one to form the final products. The radiosynthesis of 18F-FMTP needs approximatively 110 min with an overall radiochemical yield of 19.5% (decay-corrected) and with highly effective specific activities(>37 GBq/μmol) . 18F-FMTP may be a useful positron emission tomography (PET) tracer that can be applied to map brain dopamine D4 receptor
Additional details
Publishing Information
- Journal Title
- Journal of Nuclear and Radiochemistry
- Journal Volume
- 25
- Journal Issue
- 3
- Journal Page Range
- p. 151-155
- ISSN
- 0253-9950
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 35092986
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CHEMICAL PREPARATION; CONTRAST MEDIA; DOPAMINE; FLUORINE 18; KETONES; LABELLING; POSITRON COMPUTED TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTORS; USES
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEMBRANE PROTEINS; NANOSECONDS LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS; TOMOGRAPHY