Study of some parameters of the fibrinogen - fibrin transformation reaction
Creators
- 1. Commissariat a l'Energie Atomique, Grenoble (France). Centre d'Etudes Nucleaires
Description
The authors studied the action of some parameters on the reaction of transformation fibrinogen-fibrin. The five parameters studied are: the concentration of substratum: a certain quantity of enzyme determines an optimum quantity of fibrinogen; the concentration of enzyme: a certain quantity of substratum defines an optimum quantity of enzyme, beyond which the excess of enzyme is unable to act, the substratum being saturated by the enzyme; the concentration of Ca ions: between 0,07 and 0,10 mg of Ca by mg of fibrinogen, the reaction appears with a great speed. Between 0,02 and 0,40 mg of Ca by mg of fibrinogen the fibrin stabilisation is possible, the FSF can act only inside the definite bounds; the ph of the solution: the reaction of the transformation appears with its maximum intensity on physiological ph, the polymerisation is not possible on acid ph; the temperature has an effect which could not really be verified owing to the fact that the technical realisation is difficult. (author)
Availability note (English)
Available from INIS in electronic formAbstract (French)
Les auteurs etudient l'action de certains parametres sur la reaction de transformation du fibrinogene en fibrine. Les cinq parametres etudies sont: la concentration du substrat: une quantite d'enzyme donnee determine une quantite optimale de fibrinogene; la concentration en enzyme: une quantite donnee de substrat definit une quantite optimale d'enzyme; au dela de laquelle l'exces d'enzyme ne peut agir, le substrat etant sature en enzyme; la concentration en ions Ca: entre 0,07 et 0,10 m g Ca par mg fibrinogene, la reaction se manifeste a grande vitesse, entre 0,02 et 0,40 mg Ca par mg fibrinogene, la stabilisation de la fibrine est possible. Le FSF ne peut agir que dans les limites definies; le pH du milieu: la reaction de transformation se manifeste avec son maximum d'intensite au pH physiologique. A pH acide, la polymerisation est impossible; la temperature a un effet qui n'a pu etre reellement controle du fait de la difficulte de realisations techniques. (auteur)Files
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Additional details
Additional titles
- Original title (French)
- Etude de quelques parametres de la reaction de transformation du fibrinogene en fibrine
Publishing Information
- Imprint Pagination
- 30 p.
- Report number
- CEA-R--2958
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 36049756
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
- Descriptors DEI
- CALCIUM; CHEMICAL COMPOSITION; CONCENTRATION RATIO; ENZYMES; FIBRIN; FIBRINOGEN; PARAMETRIC ANALYSIS; PH VALUE; TEMPERATURE DEPENDENCE
- Descriptors DEC
- ALKALINE EARTH METALS; BLOOD COAGULATION FACTORS; ELEMENTS; GLOBULINS; METALS; ORGANIC COMPOUNDS; PROTEINS; SCLEROPROTEINS
Optional Information
- Notes
- 4 refs.