Quantitative determination of pertechnetate by electrochemical methods. Electrochemistry of technetium radiopharmaceutical analogs

Electroanalytical methods are described for obtaining quantitative information about pertechnetate in various matrices and qualitative information about analogs to commercially used /sup 99m/Tc skeletal imaging agents. An anodic stripping voltammetry method for determining pertechnetate is described that addresses the problem of multiple asymmetrical stripping waves occurring at solid electrodes. Lower detection limits are needed however, for determining pertechnetate in two matrices of specific interest, i.e., 99Mo//sup 99m/Tc generator eluents and environmental samples. A detailed discussion of a search for a well behaved pertechnetate reduction wave is followed by a description of the liquid chromatography/reductive electrochemical detection (LCEC) method developed for determining pertechnetate. The development of electroanalytical methods suitable for characterizing technetium methylene diphosphonate and technetium hydroxyethylidene reaction mixtures prepared by reduction of pertechnetate with NaBH4 is presented