Published 1975 | Version v1
Journal article Metadata-only

Comparative kinetics of 45Ca and 89Sr in chronic uremic syndrome in the rat

Creators

  • 1. Basel Univ. (Switzerland). Inst. fuer Pathologie
  • 2. Basel Univ. (Switzerland). Inst. fuer Roentgendiagnostik und Strahlentherapie
  • 3. Sandoz A.G., Basel (Switzerland). Abt. Experimentelle Therapie

Description

In rats a chronic uremic syndrome was induced by 5/6 resection and subsequent X irradiation of the kidneys. After 5 weeks 45Ca and 89Sr were injected simultaneously, and the different metabolic handling of the two elements was determined applying an open two-compartment model of Calcium kinetics. The uremic animals were compared with two groups of rats which were pairfed, and fed ad libitum, respectively. Besides an elevenfold faster urinary excretion when calculated with Sr, and which was reduced to about one half in the uremic rats, a significant discrimination by bone in favour of Ca was found, with a rather stable factor of 1.2 in the three groups. This is considered to evidence that urinary excretion and bone uptake of Sr are independent processes. (orig.)

Abstract (German)

Bei Ratten wurde durch 5/6 Resektion und nachfolgende Roentgenbestrahlung der Nieren ein chronisches uraemisches Syndrom erzeugt. Nach 5 Wochen wurden 45 Ca und 89 Sr gleichzeitig injiziert und das unterschiedliche Verhalten der beiden Elemente anhand eines offenen kinetischen Modells des Calciumstoffwechsels mit zwei Compartimenten untersucht. Die uraemischen Tiere wurden mit je einer paar- und einer ad libitum gefuetterten Gruppe verglichen. Neben einer elffach schnelleren Urinausscheidung, bei Berechnung mit Sr, die bei den uraemischen Ratten auf etwa die Haelfte reduziert war, fand sich eine signifikante Diskriminierung des Knochens zugunsten von Ca; der ziemlich konstante Faktor betrug 1,2 in allen drei Gruppen. Dies wird als Beweis angesehen, dass Urin-Ausscheidung und Knochenaufnahme von Sr voneinander unabhaengige Prozesse sind. (orig.)

Additional details

Identifiers

DOI
10.1007/bf01971387;

Publishing Information

Journal Title
Research in Experimental Medicine
Journal Volume
165
Journal Issue
3
Series
Res. Exp. Med.
Journal Page Range
271-284
ISSN
0300-9130

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
8286841
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL MODELS; CALCIUM 45; COMPARTMENTS; EXCRETION; INJECTION; METABOLISM; RADIONUCLIDE KINETICS; RATS; STRONTIUM 89; UREMIA
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CALCIUM ISOTOPES; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-ODD NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; ISOTOPES; KINETICS; MAMMALS; NUCLEI; RADIOISOTOPES; RODENTS; STRONTIUM ISOTOPES; SYMPTOMS; UROGENITAL SYSTEM DISEASES; VERTEBRATES

Optional Information

Notes
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