Published 1990 | Version v1
Report Metadata-only

A new versatile method for the synthesis of aminethiol ligands

Creators

  • 1. George Washington Univ., Washington, DC (United States)
  • 2. Univ. of Pennsylvania, Philadelphia (United States)

Description

A new method for the synthesis of aminethiol ligands, including mono and disubstituted diaminedithiol and multidentate aminethiol ligands, has been developed. Benzylmercaptan is reacted with ethyl-2-bromoisobutyrate, and the product is hydrolyzed to yield the acid. The acid is converted to acid chloride with thionyl chloride. The acid chloride is then added to amines in the presence of triethylamine, the resulting amide is reduced with borane, followed by debenzylation with sodium/liquid ammonia to give the free mercaptan compound

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 25-27.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23029470
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
AMINES; AMMONIA; BORANES; CHEMICAL PREPARATION; DITHIOLS; LIGANDS; MOLECULAR STRUCTURE; ORGANIC ACIDS; REACTION INTERMEDIATES; SODIUM; THIOLS
Descriptors DEC
ALKALI METALS; BORON COMPOUNDS; ELEMENTS; HYDRIDES; HYDROGEN COMPOUNDS; METALS; NITROGEN COMPOUNDS; NITROGEN HYDRIDES; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; REAGENTS; SYNTHESIS

Optional Information

Secondary number(s)
CONF-9006363--Absts.