Published 1987 | Version v1
Journal article Metadata-only

sup(99m)Tc-2,3-diaminopropionic acid complex as renal function agent: comparison of biological properties with sup(99m)Tc-DTPA and 131I-OIH

Creators

  • 1. Indian Inst. of Chemical Biology, Calcutta
  • 2. Kothari Centre for Gastroenterology, Calcutta (India)

Description

The preparation, purification, biodistribution, blood disappearance kinetics and imaging characteristics of sup(99m)Tc-2,3-diamino propionic acid (sup(99m)Tc-DAPA) is studied. The latter three studies were conducted on rabbits as the experimental animal and the data thus obtained were compared with sup(99m)Tc-diethylenetriaminepentaacetic acid (sup(99m)Tc-DTPA) and 131I-orthoiodohippurate (131I-OIH) with a view to find a possible replacement of the latter radiopharmaceutical with a more convenient sup(99m)Tc based compound. Preliminary data indicates favourable results for sup(99m)Tc-2,3-diamino propionic acid which warrants further investigation. (author)

Additional details

Publishing Information

Journal Title
Nucl. Med. Biol.
Journal Volume
14
Journal Issue
6
Series
Nucl. Med. Biol.
Journal Page Range
599-604
ISSN
0883-2897
CODEN
NMBIE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
19032583
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BLADDER; BLOOD-PLASMA CLEARANCE; COMPARATIVE EVALUATIONS; DTPA; HIPPURAN; IODINE 131; KIDNEYS; ORGANIC NITROGEN COMPOUNDS; PROPIONIC ACID; RABBITS; RADIOPHARMACEUTICALS; SCINTISCANNING; TECHNETIUM COMPLEXES; TECHNETIUM 99; TISSUE DISTRIBUTION
Descriptors DEC
AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEARANCE; COMPLEXES; CONTRAST MEDIA; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISTRIBUTION; DRUGS; EVALUATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; URINARY TRACT; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
A preliminary report of this work appeared in IRCS (London), v. 14 p. 266 (1986).