Intra- and inter-observer variability in dependence of T1-time correction for common dynamic contrast enhanced MRI parameters in prostate cancer patients

BackgroundDynamic contrast enhanced (DCE) MRI parameters are potential biomarkers to characterise tumour vasculature and distinguish it from the non-cancerous blood vessel system within the prostate. However, the inevitable presence of intra- and inter-observer variabilities is challenging in this context. Additionally, pre-contrast T1-time correction is a prerequisite to gain quantitative DCE parameters in the first place. The current study investigated the effect of individualized T1-time correction on intra- and inter-reader variability for quantitative DCE-parameters in prostatic lesions.