Published January 1976
| Version v1
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Removal of intratracheally intubated 253Es(NO3)3 from rats by inhaled or injected Ca- or Zn-DTPA
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Description
Twenty-seven days after the intratracheal instillation of 253Es(NO3)3 to rats, Ca-DTPA, Zn-DTPA, or mixtures of the two, were given by inhalation or intraperitoneal injection for a series of nine treatments spaced over 3 weeks. The cation had no effect on treatment effectiveness but administration by injection may give better removal of Es from the liver than does inhalation. High doses of the chelating agent remove more Es, though the magnitude of this effect decreases with the number of treatments. Increased retention of Es was observed in the lungs of most treated rats
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Additional details
Publishing Information
- Imprint Title
- Pacific Northwest Laboratory annual report for 1975 to the ERDA Division of Biomedical and Environmental Research. Part 1. Biomedical Sciences
- Imprint Pagination
- p. 141-143.
- Report number
- BNWL--2000(Pt.1)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 7268523
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- DECONTAMINATION; DTPA; EINSTEINIUM NITRATES; EINSTEINIUM 253; INHALATION; INTRAPERITONEAL INJECTION; LIVER; LUNGS; RATS; RETENTION
- Descriptors DEC
- ACTINIDE COMPOUNDS; ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; CHELATING AGENTS; CLEANING; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; EINSTEINIUM COMPOUNDS; EINSTEINIUM ISOTOPES; GLANDS; HEAVY NUCLEI; INJECTION; INTAKE; ISOTOPES; MAMMALS; NITRATES; NITROGEN COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; TRANSURANIUM COMPOUNDS; VERTEBRATES