Published September 1985 | Version v1
Journal article

Synthesis and configurational studies on 2,5,5-trisubstituted-1,3-dioxanes

  • 1. Natal Univ., Pietermaritzburg (South Africa). Dept. of Chemistry
  • 2. Council for Scientific and Industrial Research, Pretoria (South Africa). National Chemical Research Lab.

Description

Using 13C n.m.r. as probe, the mechanism for the ready isomerization of 5-acetyl-5-methyl-2-phenyl-1,3-dioxane under very mild acid conditions was studied. From a detailed study (13C n.m.r. and 1H n.m.r.) of additional trisubstituted-1,3-dioxanes, empirical correlations relating to the stereochemistry of these 1,3-dioxanes have been formulated. Free energy values obtained for the series of dioxanes reflect very clearly the influence of the C(2) substituent on the equilibrium

Additional details

Publishing Information

Journal Title
S. Afr. J. Chem.
Journal Volume
38
Journal Issue
3
Series
S. Afr. J. Chem.
Journal Page Range
101-106
ISSN
0379-4350
CODEN
SAJCD