Published 1979 | Version v1
Journal article Metadata-only

Therapy of psoriasis with retinoid plus PUVA

Creators

  • 1. Kiel Univ. (Germany, F.R.). Abt. Dermatologie und Venerologie

Description

In a group of 40 patients suffering from wide-spread psoriasis oral administration of a retinoid (Ro 10-9359) was followed by PUVA therapy. The clearance rate was increased by 30% as compared to PUVA alone. Except for cheilitis no side effects were seen. Histological analysis in 20 patients before, during and after therapy revealed an intensification of psoriatic tissue changes after retinoid treatment. Loss of corneal layers, massive exoserosis, and neutrophil migration were prominent features. Mitotic counts were not increased by the pretreatment. The increased susceptibility of diseased skin to PUVA as produced by this drug appears to be based on several factors related to the tissue changes revealed by histology. (orig.)

Abstract (German)

Vierzig Patienten mit ausgedehnter Psoriasis vulgaris wurden mit einem Retinoid (Ro 10-9359)ueber 2 Wochen vorbehandelt. Anschliessend erfolgte eine zusaetzliche Therapie mit PUVA. Die Hautveraenderungen heilten im Vergleich zu PUVA allein signifikant schneller ab. Ausser einer Cheilitis fanden sich keine auffaelligen Nebenwirkungen. Histologisches Merkmal der retinoid-induzierten Gewebsveraenderungen waren weitgehender Verlust des Stratum corneum, Exoserose und eine starke Exocytose von Neutrophilen. Die mitotische Aktivitaet der retinoid-vorbehandelten Psoriasis war nicht veraendert. Die hoehere Empfindlichkeit der retinoid-vorbehandelten Haut gegenueber der nachfolgenden PUVA-Therapie beruht moeglicherweise auf mehreren Faktoren, die mit den histologisch sichtbaren Gewebsveraenderungen korrelieren. (orig.)

Additional details

Additional titles

Subtitle (English)
Clinical and histologic data

Publishing Information

Journal Title
Arch. Dermatol. Res.
Journal Volume
264
Series
Arch. Dermatol. Res.
Journal Page Range
331-337

Conference

Title
Niels-Stenson-symposium.
Dates
28 Oct 1978.
Place
Appenrade, Denmark.

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
11500002
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CLEARANCE; DELAYED RADIATION EFFECTS; ORAL ADMINISTRATION; PATHOLOGICAL CHANGES; PATIENTS; PSORIASIS; RADIOTHERAPY; RESPONSE MODIFYING FACTORS; SKIN; ULTRAVIOLET RADIATION
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; MEDICINE; ORGANS; RADIATION EFFECTS; RADIATIONS; SKIN DISEASES; THERAPY