Published 1990 | Version v1
Report Metadata-only

Synthesis and evaluation of (S)-5-[125I]iodo-2,3-methylenedioxybenzamide

Creators

  • 1. Lawrence Berkeley Lab., CA (United States)
  • 2. Univ. of North Carolina, Chapel Hill (United States)

Description

Recent reports have demonstrated that benzamides possessing 2,3-dimethoxy-5-iodo- and 2,3-dihydroxybenzofuran-5-iodo- substitution patterns (termed epidepride and IBF, respectively) are potent dopamine D-2 antagonists. A closely related benzamide ((S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2,3-methylenedioxy-5-[I-125]iodo-benzamide, termed IMD) has been synthesized and its activity compared to that of epidepride and IBF. The synthetic pathway and both in vitro and in vivo behavior of the compound are discussed

Additional details

Publishing Information

Imprint Title
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report
Imprint Pagination
458 p.
Journal Page Range
p. 370.
Report number
DOE/ER/60968--1

Conference

Title
8. international symposium on radiopharmaceutical chemistry.
Dates
24-29 Jun 1990.
Place
Princeton, NJ (United States).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
23029820
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
AMIDES; CHEMICAL PREPARATION; DOPAMINE; EVALUATION; IN VITRO; IN VIVO; IODINE 125; LABELLING; MEMBRANES; MOLECULAR STRUCTURE; RADIOPHARMACEUTICALS; RECEPTORS; SINGLE PHOTON ECT; TISSUE DISTRIBUTION; TRITIUM
Descriptors DEC
AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Contract AC03-76SF00098
Secondary number(s)
CONF-9006363--Absts.