Variations in the SH-content of haploid yeast and their relevance to radiosensitivity
Description
An investigation has been carried out into the radioprotective role of endogenous non-protein sulphydryls (NPSH) in Saccharomyces cerevisiae. Large (14-fold) variations in NPSH content (induced through starving the cells and/or treating with N-ethylmaleimide) proved not to affect the sensitivity to 220 keV X-rays when cells were irradiated under fully oxygenated or extremely hypoxic conditions. However, at low oxygen concentrations, a reduction in NPSH resulted in enhanced radiosensitivity. These observations, which can be explained in terms of competition for the same target between sulphydryls and oxygen, demonstrate that physiological variations in the endogenous sulphydryl content are of minor importance for the expression of X-ray damage in haploid yeast. (U.K.)
Additional details
Identifiers
Publishing Information
- Journal Title
- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Journal Volume
- 32
- Journal Issue
- 3
- Series
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Page Range
- 285-292
- ISSN
- 0020-7616
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 9349718
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; FASTING; NEM; QUANTITY RATIO; RADIOSENSITIVITY; RESPONSE MODIFYING FACTORS; SACCHAROMYCES; SURVIVAL CURVES; THIOLS; TIME DEPENDENCE; X RADIATION
- Descriptors DEC
- BIOLOGICAL EFFECTS; DRUGS; ELECTROMAGNETIC RADIATION; FUNGI; IMIDES; IONIZING RADIATIONS; MICROORGANISMS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PLANTS; RADIATION EFFECTS; RADIATIONS; RADIOSENSITIZERS; YEASTS
Optional Information
- Notes
- Updated automatically by Metadata and Full-Text Enrichment Agent