Published December 2003 | Version v1
Journal article Metadata-only

Change of cell cycle arrest of tumor cell lines after 60Co γ-irradiation

Creators

  • 1. Tongji Medical College of Huazhong Science and Technology Univ., Wuhan (China). The Hematology Dept. of Tongji Hospital

Description

Objective: To observe the cell cycle arrest changes in peripheral blood mononuclear cells (PBMNCs) of normal persons and several kinds of tumor cell lines after 60Co γ-irradiation. Methods: PBMNCs of normal persons, HL-60, K562, SiHA and 113 tumor cell lines were irradiated with 60Co γ-rays at the absorbed doses of 6, 10,15 Gy. Cell cycles changes were checked 6, 12, 24, 48 and 60 h after the irradiation. Results: A stasis state was observed in normal person PBMNCs, 95 percents of which were in G1 phase, and they still remained stasis after the irradiation. Except the 113 cell line manifesting G1 phase arrest, all other tumor cell lines showed G2/M phase arrest after irradiation. The radiation sensitivity of HL-60 was higher than that of SiHA cell line. Conclusion: Different cell lines have different cell cycle arrest reaction to radiation and their radiation sensitivity are also different

Additional details

Publishing Information

Journal Title
Chinese Journal of Radiological Medicine and Protection
Journal Volume
23
Journal Issue
6
Journal Page Range
p. 418-420
ISSN
0254-5098

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
35093025
Subject category
RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Quality check status
Yes
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CYCLE; COBALT 60; GAMMA RADIATION; RADIOSENSITIVITY; TUMOR CELLS;
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; COBALT ISOTOPES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; YEARS LIVING RADIOISOTOPES;